The e-Lab is formed by talented researchers that share the ambition to crack the most mysterious aspects of epilepsy. One unifying question we have is “why do seizures occur at particular moments in time?”. We use a translational approach to the question using big data in patients and neuronal manipulations in animal models.
Group members and their position
Kristina Slabeva, master student Grégory Lepeu, MD-PhD student Marc Grau, Postdoctoral Fellow
Previous and current research
We study the temporal structure of epilepsy at multiple time-scales using a broad electrophysiological arsenal in a number of settings: • In ambulatory patients equipped with devices for chronic EEG • In inpatients undergoing intracranial monitoring • In animals using optogenetic and pharmacologic
The Chronobiology of Epilepsy The Temporal Structure of Epilepsy Forecasting Seizure Risk
Techniques / methods
Scalp, subscalp and intracranial Electroencephalography, multi-unit recordings, optogenetics
Neuralynx, open-BCI, etc.
M Baud and V Rao, Gauging Seizure Risk, Neurology, 2018 M Baud, J Kleen, E Mirro, J Andrechak, D King-Stephens, E Chang, V Rao, Multi-day rhythm modulate seizure risk in epilepsy. Nature Communications, 2018 M Baud, J Kleen, G Anumanchipalli, L Hamilton, YL Tan, R Knowlton, E Chang. Unsupervised learning of spatiotemporal interictal discharges in folcal epilepsy. Neurosurgery, 2017. M Leonard, M Baud, M Sjerps, E Chang. Perceptual Restoration of Masked Speech in Human Cortex. Nature Communications, 2016.
Selected lectures, seminars, colloquia
Swiss National Science Foundation University of Bern Wyss Center for Neuroengineering Velux Foundation